INHIBITION OF ENZYMES BY PHENYLMERCURY COMPOUNDS* BY SISTER MARIE AUGUSTINE SMALT,t CORNELIUS W. KREKE,
نویسنده
چکیده
Cytochrome oxidase and catalase are not regarded as sulfhydryldependent enzymes (1). The inhibition of the former by organic mercurial compounds (2) has been thought to involve denaturation (3) rather than interaction with sulfhydryl groups, and it has been suggested that the mercurial inhibition of catalase is also non-specific (4). Because the protein molecule contains reactive groups other than sulfhydryl, it is conceivable that the mercurial compounds might inhibit by interaction with such groups. Therefore, we have tested the ease of reaction of the phenylmercury ion with such groups in simple compounds. The resulting mercury compounds have, in turn, been compared to phenylmercury hydroxide for their effects on the cytochrome oxidase, succinic dehydrogenase, and succinoxidase systems.
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